Journal
JOURNAL OF CONTROLLED RELEASE
Volume 162, Issue 1, Pages 45-55Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2012.05.051
Keywords
Emerging multidrug resistance; Nanotechnology; Drug delivery system; Chemotherapy; Tumor
Funding
- Natural Science Foundation of China (NSFC) [30801444]
- Natural Science Foundation of Hebei Province [C2009000693, H2012208020]
- Hebei University of Science and Technology Discipline Construction Office
- State Key Laboratory Breeding Base-Hebei Key Laboratory of Molecular Chemistry For Drug
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Emerging multidrug resistance (MDR) to chemotherapy is amajor obstacle in successfully treatingmalignant diseases. Nanotechnology provides an innovative and promising alternative strategy compared to conventional small molecule chemotherapeutics to circumvent MDR. This review focuses on recent literature examples of nanotechnology applications to overcome MDR. The advantages and limitations of various nanotechnologies are discussed as well as possible approaches to overcome the limitations. Developing a practical nanotechnology-based drug delivery system requires further studies of the tumor microenvironment, the mechanisms of MDR to chemotherapy, the optimal dosage regimen of anticancer drugs and/or siRNA, the transport kinetics of nanocarriers in tumor stroma and the pharmacokinetics of drug-loaded nanocarriers within MDR tumor cells. (C) 2012 Elsevier B. V. All rights reserved.
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