Journal
JOURNAL OF CONTROLLED RELEASE
Volume 155, Issue 3, Pages 344-357Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2011.06.004
Keywords
Theranostics; Quantum dots; Gold nanoparticles; Carbon nanotubes; Ceramic nanoparticles; Magnetic nanoparticles
Funding
- National Cancer Institute, National Institutes of Health [5R21CA133618-02]
- National Science Foundation [CBET-0829128]
- California Breast Cancer Research Program [14FB-0107]
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Inorganic nanoparticles have received increased attention in the recent past as potential diagnostic and therapeutic systems in the field of oncology. Inorganic nanoparticles have demonstrated successes in imaging and treatment of tumors both ex vivo and in vivo, with some promise towards clinical trials. This review primarily discusses progress in applications of inorganic nanoparticles for cancer imaging and treatment, with an emphasis on in vivo studies. Advances in the use of semiconductor fluorescent quantum dots, carbon nanotubes, gold nanoparticles (spheres, shells, rods, cages), iron oxide magnetic nanoparticles and ceramic nanoparticles in tumor targeting, imaging, photothermal therapy and drug delivery applications are discussed. Limitations and toxicity issues associated with inorganic nanoparticles in living organisms are also discussed. (C) 2011 Elsevier B.V. All rights reserved.
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