Journal
JOURNAL OF CONTROLLED RELEASE
Volume 155, Issue 2, Pages 119-127Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2011.06.009
Keywords
Responsive hydrogels; Oral delivery; Protein delivery; Nanoscale hydrogels; Interpenetrating network
Funding
- NCI NIH HHS [U54 CA143837, U54-CA-143837] Funding Source: Medline
- NIBIB NIH HHS [R01 EB000246-17A2, R01 EB000246-18, R01 EB000246] Funding Source: Medline
- NIGMS NIH HHS [R01 GM043337-08A1, R01 GM043337] Funding Source: Medline
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1033746] Funding Source: National Science Foundation
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Hydrogels have been instrumental in the development of polymeric systems for controlled release of therapeutic agents. These materials are attractive for transmucosal and intracellular drug delivery because of their facile synthesis, inherent biocompatibility, tunable physicochemical properties, and capacity to respond to various physiological stimuli. In this contribution, we outline a multifaceted hydrogel-based approach for expanding the range of therapeutics in oral formulations from classical small-molecule drugs to include proteins, chemotherapeutics, and nucleic acids. Through judicious material selection and careful design of copolymer composition and molecular architecture, we can engineer systems capable of responding to distinct physiological cues, with tunable physicochemical properties that are optimized to load, protect, and deliver valuable macromolecular payloads to their intended site of action. These hydrogel carriers, including complexation hydrogels, tethered hydrogels, interpenetrating networks, nanoscale hydrogels, and hydrogels with decorated structures are investigated for their ability to respond to changes in pH, to load and release insulin and fluorescein, and remain non-toxic to Caco-2 cells. Our results suggest these novel hydrogel networks have great potential for controlled delivery of proteins, chemotherapeutics, and nucleic acids. (C) 2011 Elsevier B.V. All rights reserved.
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