Journal
JOURNAL OF CONTROLLED RELEASE
Volume 152, Issue 1, Pages 99-109Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2011.01.013
Keywords
Non-viral carrier; Gene therapy; Nuclear targeting; Cytoplasm targeting; Mitochondria targeting
Funding
- Korea Science and Engineering Foundation [2010K001247, 2010K001350]
- Ministry of Education, Science, and Technology [R332008000100360]
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Gene therapy is a rapidly growing approach for the treatment of various diseases. To achieve successful gene therapy, a gene delivery system is necessary to overcome several barriers in the extracellular and intracellular spaces. Polymers, peptides, liposomes and nanoparticles developed as gene carriers have achieved efficient cellular uptake of genes. Among these carriers, cationic polymers and peptides have been further developed as intracellular organelle-targeted delivery systems. The cytoplasm, nucleus and mitochondria have been considered primary targets for gene delivery using targeting moieties or environment-responsive materials. In this review, we explore recently developed non-viral gene carriers based on reducible systems specialized to target the cytoplasm, nucleus and mitochondria. (C) 2011 Elsevier B.V. All rights reserved.
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