Journal
JOURNAL OF CONTROLLED RELEASE
Volume 139, Issue 2, Pages 160-166Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2009.06.010
Keywords
Smart capsule; Water-soluble drug; Encapsulation; Layer-by-layer assembly
Funding
- National Nature Science Foundation of China [20520130213]
- National Basic Research Program of China (973 program) [2007CB935900]
- EU project Active BIOMICS TTC [NMP4-CT-2004516989]
- Chinese Academy of Sciences as well as the German MaxPlank Society
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Heat treatment is introduced as a simple method for the encapsulation of low molecular weight water-soluble drugs within layer-by-layer assembled microcapsules. A water-soluble drug, procainamide hydrochloride, could thus be encapsulated in large amount and enriched by more than 2 orders of magnitude in the assembled PDADMAC/PSS capsules. The shrunk capsules could control the unloading rate of drugs, and the drugs could be easily unloaded using ultrasonic treatment. The encapsulated amount could be quantitatively controlled via the drug concentration in the bulk. We also found that smaller capsules possess higher encapsulation capability. (C) 2009 Elsevier B.V. All rights reserved.
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