Journal
JOURNAL OF CONTROLLED RELEASE
Volume 135, Issue 1, Pages 89-95Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2008.12.008
Keywords
Volume transition nanogels; Stimuli-sensitive hydrogels; Membrane disruption; Cell death
Funding
- Korea Science and Engineering Foundation, Republic of Korea
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Here we report a novel class of super-expandable smart nanogels that undergo nano- to micro-scale volume transition in response to temperature change, applicable for thermally triggered death of cancer cells. The nanogels fabricated by light cross-linking between oligo(L-lactic acid)-poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)-OligO(L-lactic acid) and poly(ethylene glycol) grafted poly(L-lysine) exhibited a reversible volume transition from similar to 150 nm at 37 degrees C to similar to 1.4 mu m at 15 degrees C. The abrupt and dramatic intracellular volume expansion of the nanogels upon the brief cold-shock treatment severely damaged sub-cellular self-assembled network architectures including cytoskeleton and vesicular membranes and physically ruptured cellular membrane structures, resulting in necrotic cell death. The smart nanobomb detonated by external stimuli could be used to effectively induce traumatic death of cells. (C) 2008 Elsevier B.V. All rights reserved
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