Journal
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
Volume 34, Issue 6, Pages 949-957Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RCT.0b013e3181ec05e4
Keywords
osteoporosis; multidetector CT; texture analysis; bone mineral density; proximal femur
Funding
- AO Foundation, Davos, Switzerland
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Objective: The objectives of this study were to perform a clinical study analyzing bone quality in multidetector computed tomographic images of the femur using bone mineral density (BMD), cortical thickness, and texture algorithms in differentiating osteoporotic fracture and control subjects; to differentiate fracture types. Methods: Femoral head, trochanteric, intertrochanteric, and upper and lower neck were segmented (fracture, n = 30; control, n = 10). Cortical thickness, BMD, and texture analysis were obtained using co-occurrence matrices, Minkowski dimension, and functional and scaling index method. Results: Bone mineral density and cortical thickness performed best in the neck region, and texture measures performed best in the trochanter. Only cortical thickness and texture measures differentiated femoral neck and intertrochanteric fractures. Conclusions: This study demonstrates that differentiation of osteoporotic fracture subjects and controls is achieved with texture measures, cortical thickness, and BMD; however, performance is region specific.
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