Journal
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
Volume 32, Issue 5, Pages 792-798Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/RCT.0b013e31815688ae
Keywords
lung cancer; ground-glass opacity; 5-year relapse-free survival; GGO measurement
Funding
- Ministry of Health, Labor and Welfare, Tokyo, Japan [13-8]
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Objective: To evaluate the performance of 4 methods of measuring the extent of ground-glass opacities as a means of predicting the 5-year relapse-free survival of patients with peripheral nonsmall cell lung cancer (NSLC). Methods: Ground-glass opacities on thin-section computed tomographic images of 120 peripheral NSLCs were measured at 7 medical institutions by the length, area, modified length, and vanishing ratio (VR) methods. The performance (Az) of each method in predicting the 5-year relapse-free survival was evaluated using receiver operating characteristic analysis. Results: The mean Az value obtained by the length, area, modified length, and VR methods in the receiver operating characteristic analyses was 0.683, 0.702, 0.728, and 0.784, respectively. The differences between the mean Az value obtained by the VR method and by the other 3 methods were significant. Conclusions: Vanishing ratio method was the most accurate predictor of the 5-year relapse-free survival of patients with peripheral NSLC.
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