Journal
JOURNAL OF COMPUTATIONAL BIOLOGY
Volume 19, Issue 5, Pages 532-549Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/cmb.2011.0197
Keywords
algorithms; alignment; RNA; secondary structure; sequence analysis
Categories
Funding
- Grants-in-Aid for Scientific Research [22240031, 221S0002] Funding Source: KAKEN
Ask authors/readers for more resources
Many estimation problems in bioinformatics are formulated as point estimation problems in a high-dimensional discrete space. In general, it is difficult to design reliable estimators for this type of problem, because the number of possible solutions is immense, which leads to an extremely low probability for every solution-even for the one with the highest probability. Therefore, maximum score and maximum likelihood estimators do not work well in this situation although they are widely employed in a number of applications. Maximizing expected accuracy (MEA) estimation, in which accuracy measures of the target problem and the entire distribution of solutions are considered, is a more successful approach. In this review, we provide an extensive discussion of algorithms and software based on MEA. We describe how a number of algorithms used in previous studies can be classified from the viewpoint of MEA. We believe that this review will be useful not only for users wishing to utilize software to solve the estimation problems appearing in this article, but also for developers wishing to design algorithms on the basis of MEA.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available