Journal
JOURNAL OF COMPUTATIONAL BIOLOGY
Volume 17, Issue 3, Pages 477-487Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/cmb.2009.0178
Keywords
algorithms; combinatories; NP-completeness
Categories
Funding
- NIH [1R01GM080330-01A1, R21 LM004911]
- NSF [ASE+NHS(dms)0428715]
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Between-pathway models (BPMs) are network motifs consisting of pairs of putative redundant pathways. In this article, we show how adding another source of high-throughput data-microarray gene expression data from knockout experiments-allows us to identify a compensatory functional relationship between genes from the two BPM pathways. We evaluate the quality of the BPMs from four different studies, and we describe how our methods might be extended to refine pathways.
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