Journal
JOURNAL OF COMPUTATIONAL BIOLOGY
Volume 15, Issue 9, Pages 1133-1153Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/cmb.2008.0065
Keywords
gene clusters; genomic rearrangements; strings; recombinations; ARG
Categories
Funding
- Spanish Ministry of Science [FPU AP2006-03268, BFU-63657]
Ask authors/readers for more resources
Traditionally nonrecombinant genome, i.e., mtDNA or Y chromosome, has been used for phylogeography, notably for ease of analysis. The topology of the phylogeny structure in this case is an acyclic graph, which is often a tree, is easy to comprehend and is somewhat easy to infer. However, recombination is an undeniable genetic fact for most part of the genome. Driven by the need for a more complete analysis, we address the problem of estimating the ancestral recombination graph (ARG) from a collection of extant sequences. We exploit the coherence that is observed in the human haplotypes as patterns and present a network model of patterns to reconstruct the ARG. We test our model on simulations that closely mimic the observed haplotypes and observe promising results.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available