Journal
JOURNAL OF COMPARATIVE PATHOLOGY
Volume 146, Issue 4, Pages 332-337Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jcpa.2011.08.005
Keywords
aquaporin; hydronephrosis; mouse; mutant
Categories
Ask authors/readers for more resources
This study investigates the expression of aquaporin-1, -2 and -4 in mice with a spontaneously-arising mutation that leads to hydronephrosis (ICR/Mlac-hydro mice). The mutant mice developed bilateral non-obstructive hydroncphrosis without evidence of interstitial fibrosis or glomerulosclerosis. The mice had no abnormality in blood urea nitrogen or creatinine concentrations or in urine specific gravity. Despite the severity of the renal damage the mice grew and reproduced normally. Kidneys from the mutant mice had reduced expression of all three aquaporins compared with wild type mice. The reduction in aquaporin was proportional to the degree of hydronephrosis, but this change did not appear to be associated with disturbance of urinary function. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available