Journal
JOURNAL OF COMPARATIVE PATHOLOGY
Volume 144, Issue 2-3, Pages 157-163Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jcpa.2010.08.006
Keywords
angiogenesis; canine mammary carcinomas; mast cell; mast cell tryptase
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Funding
- Konkuk University Research Foundation
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Angiogenesis plays a crucial role in tumour growth, invasion and metastasis. Mast cells (MCs) release angiogenic factors that promote endothelial proliferation and differentiation. Previous studies have suggested that MCs are involved in tumour angiogenesis due to the release of various pro-angiogenic factors. This study evaluated samples from 40 canine mammary carcinomas and eight healthy non-neoplastic canine mammary glands. Toluidine blue staining was performed to characterize the MCs. Immunohistochemical labelling was performed to detect the number of tryptase-positive MCs and microvessels. MCs accumulated in tumour tissue and were closely associated with blood or lymphatic vessels in the tumour microenvironment. Angiogenesis, as measured by microvessel density, increased in direct proportion to the number of MCs. The correlation coefficient was significantly higher for tryptase-positive MCs than for toluidine blue-stained MCs. These results suggest that MCs are involved in tumour angiogenesis, which in turn influences tumour growth, invasion and metastasis. In particular, MC tryptase may be influential in mediating this function of MCs. (C) 2010 Elsevier Ltd. All rights reserved.
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