Effect of Ageing on the Immune Response of Dogs to Vaccines

Ageing is associated with a decline in functional competence of the immune system, sometimes referred to as immunosenescence. As this increase the susceptibility of dogs to infectious disease, it is important to determine if the efficacy of vaccines is affected by ageing. Studies to date suggest that the primary response to vaccines may be compromised in old dogs, but recall responses remain intact. Information on the effect of ageing on the duration of protective immunity following vaccination is needed. (C) 2009 Elsevier Ltd. All rights reserved.