3.8 Article

Novel and Efficient One-Step Parallel Synthesis of Dibenzopyranones via Suzuki-Miyaura Cross Coupling

Journal

JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 12, Issue 5, Pages 664-669

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/cc100068a

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Funding

  1. National Institute of Health [DA007215, DA003801]
  2. National Institute of Drug Abuse

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Microwave-promoted novel and efficient one-step parallel synthesis of dibenzopyranones and heterocyclic analogues from bromo arylcarboxylates and o-hydroxyarylboronic acids via Suzuki-Miyaura cross coupling reaction is described. Spontaneous lactonization gave dibenzopyranones and heterocyclic analogues bearing electron-donating and -withdrawing groups on both aromatic rings in good to excellent yields.

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