3.8 Article

Efficient Assembly of 1-Methylene-1H-indenes via Palladium-Catalyzed Tandem Reaction of 1-(2,2-Dibromovinyl)-2-alkenylbenzene with Arylboronic Acid

Journal

JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 12, Issue 5, Pages 670-675

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/cc1000693

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Funding

  1. National Natural Science Foundation of China [20972030]
  2. Science & Technology Commission of Shanghai Municipality [09JC1404902]

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Highly efficient palladium-catalyzed reaction of 1-(2,2-dibromovinyl)-2-alkenylbenzene with arylboronic acid is disclosed, which generates the functionalized 1-methylene-1H-indenes in good yields. Tandem Suzuki-Miyaura coupling and Heck reactions are involved in this process.

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