Journal
JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 12, Issue 6, Pages 829-835Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cc100079b
Keywords
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Funding
- National Natural Science Foundation of China [20672079, 20910102041]
- Natural Science Foundation of Jiangsu Province [BK 2006048]
- Nature Science of Jiangsu Province for Higher Education [05KJB150116]
- Nature Science Key Basic Research of Jiangsu Province for Higher Education [06KJ A15007]
- Specialized Research Fund for the Doctoral Program of Higher Education [20060285001]
- Key Laboratory of Organic Synthesis of Jiangsu Province [JSK 008]
- Soochow University
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A convenient and highly efficient multicomponent protocol has been developed for the synthesis of various poly-substituted 2-(pyridin-2-yl)imidazoles from 2-cyanopyridine, corresponding aromatic aldehydes, and NH4OAc/primary amine. Notably, tri-substituted 2-(pyridin-2-yl)imidazoles were highly yielded when aromatic primary amines were used as substrates, but both di- and tri-substituted 2-(pyridin-2-yl)imidazoles were obtained in one pot when some aliphatic primary amines were used as substrates.
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