Journal
JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 12, Issue 4, Pages 488-490Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cc100021t
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Funding
- National Natural Science Foundation of China [30772652, 90813026]
- National Science & Technology Major Project Key New Drug Creation and Manufacturing Program of China [2009ZX09501-010]
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An efficient method for the solution-phase parallel synthesis of 4-substituted-1,4-dihydroisoquinolin-3-ones is developed. The isoquinolinones were constructed employing an intramolecular Heck reaction, providing full regio- and stereoselectivity. Most of the synthesized compounds showed potent antiproliferative activities against tumor cell lines.
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