Synthesis of 1-(1H-Indol-3-yl)-1,2-dihydroisoquinolines via AgOTf-Catalyzed Three-Component Reactions of 2-Alkynylbenzaldehydes, Amines, and Indoles

Three-component reactions of 2-alkynylbenzaldehydes, amines, and indoles catalyzed by AgOTf Under mild conditions afford the 1-(1H-indol-3-yl)-1,1-dihydroisoquinolines in good yields. This silver-catalyzed tandem reaction is found to be workable with various indoles. anilines or alkyl amines, and 2-alkynylbenzaldehydes with electron-withdrawing groups attached oil the aromatic backbone.