Journal
JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 12, Issue 4, Pages 604-608Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cc1000456
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Funding
- Contre le Cancer Region Grand Quest
- le Canceropole Grand Quest
- MESR
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A versatile protocol for the preparation of a library of 5,6-(het)bisarylated imidazol[1,2,b][1,2,4,5]tetrazines is described. Target compounds were obtained in fairly good yields, starting from ethoxy-7-(4-methoxyphenyl)imidazo[1,2-b][1,2,4,5]tetrazine and a large panel of bromoaryl derivatives, using palladium catalysis under microwave irradiation. Compatibility with various chemical groups and heterocycles was proven. Steric and electronic effects do not have any effect on the efficiency of the reaction. Purifications were performed without any difficulties, and the structure of a final compound was proven by crystal X-ray diffraction studies.
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