Journal
JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 11, Issue 6, Pages 1007-1010Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cc900005v
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Funding
- National Natural Science Foundation of China [20672091]
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A sequential one-pot two-step tandem reaction for efficient synthesis of polysubstituted cyclopropanes has been developed. The three-component reaction of cc-halogenated methylene compounds, aromatic aldehydes, and acetonitrile derivatives produced first the intermediates pyridinium salts and electron-deficient olefins, followed by cyclopropanation of pyridinium ylide with electron-deficient olefins in situ to afford polysubstituted cyclopropanes. Target compounds were obtained in high yields and were diastereomerically pure after recrystallization.
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