Journal
JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 11, Issue 1, Pages 44-46Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cc800118v
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Many well-known drugs contain 2-pyridone and 2-quinolone scaffolds. In the current paper, a one-pot three-step microwave-assisted method for the synthesis of NI-substituted 2,5-dioxo-1,2,5,6,7,8-hexahydro-3-quinolinecarbonitrile derivatives was developed. Employing this protocol, we quickly generated 105 compounds library from 1,3-cyclohexanediones, dimethylformamide dimethylacetal, and various cyanacetamides.
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