Rapid Three-Step One-Pot Microwave-Assisted Synthesis of 2,5-Dioxo-1,2,5,6,7,8-hexahydro-3-quinolinecarbonitrile Library

Many well-known drugs contain 2-pyridone and 2-quinolone scaffolds. In the current paper, a one-pot three-step microwave-assisted method for the synthesis of NI-substituted 2,5-dioxo-1,2,5,6,7,8-hexahydro-3-quinolinecarbonitrile derivatives was developed. Employing this protocol, we quickly generated 105 compounds library from 1,3-cyclohexanediones, dimethylformamide dimethylacetal, and various cyanacetamides.