Efficient Synthesis of Spiro[chromeno[2,3-d]pyrimidine-5,3′-indoline]-tetraones by a One-Pot and Three-Component Reaction

An efficient one-pot synthesis of novel 8,9-dihydrospiro[chromeno [2,3-d]pyrimidine-5,3'-indoline]-2,2',4, 6(1H,3H,7H)-tetraone derivatives by a three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3-diones in refluxing water in the presence of P-TSA for 10 h is reported. Two cyclohexane-1,3-diones, three barbituric acids, and eight substituted isatins were chosen for the library validation. Reaction of 5,5-dimethyl-cyclohexane-1,3-dione and acenaphthylene-1,2-dione with barbituric acids resulted in the formation of spiro[acenaphthylene-1,5'-chromeno[2,3,d]pyrmidine] derivatives.