Journal
JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 10, Issue 3, Pages 376-380Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cc800017h
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Funding
- NIGMS NIH HHS [P20GM072029] Funding Source: Medline
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A fluorescent dye library approach for the development of a bioanalyte sensor was sought. The screening of a rosamine dye library against diverse macromolecules led to the discovery of a highly sensitive human serum albumin binder, G13, with similar to 36-fold fluorescence intensity change. G13 showed a highly selective response to HSA over other macromolecules including albumins from other species. The potential use of G13 for the detection of HSA in biofluids is described.
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