Journal
JOURNAL OF COMBINATORIAL CHEMISTRY
Volume 10, Issue 5, Pages 658-663Publisher
AMER CHEMICAL SOC
DOI: 10.1021/cc800055x
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Funding
- National Institute of General Medical Sciences [R01 GM070620, R01 GM079593]
- National Institutes of Health Kansas University Chemical Methodologies and Library Development Center of Excellence [P50 GM069663]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P41GM079593, P50GM069663, R01GM070620] Funding Source: NIH RePORTER
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The iodocyclization of O-methyloximes of 2-alkyn-1-ones affords 4-iodoisoxazoles, which undergo various palladium-catalyzed reactions to yield 3,4,5-trisubstituted isoxazoles. The palladium-catalyzed processes have been adapted to parallel synthesis utilizing commercially available boronic acid, acetylene, styrene, and amine sublibraries. Accordingly, a diverse 51-member library of 3,4,5-trisubstituted isoxazoles has been generated.
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