Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 398, Issue -, Pages 51-58Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2013.01.042
Keywords
Thermoresponsive; Magnetic microspheres; 1,1-diphenylethene; Controlled release; Controlled polymerization
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Funding
- National Natural Science Foundation of China [51173146, 51173147]
- Northwestern polytechnical university [JC20120248]
- Doctorate Foundation of Northwestern Polytechnical University [CX201210]
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In this work, Fe3O4/P(acrylic acid-methyl methacrylate-N-isopropylacrylamide) (Fe3O4/P(AA-MMA-NIPAm)) thermoresponsive magnetic composite microspheres have been prepared by controlled radical polymerization in the presence of 1,1-diphenylethene (DPE). The shell thickness of thermosensitive polymer (PNIPAm), which was on the surface of the microspheres, can be controlled by using DPE method. The morphology and thermosensitive properties of the composite microspheres, polymerization mechanism of the shell were characterized by TEM, FTIR, VSM, Laser Particle Sizer, TGA, NMR, and GPC. The microspheres with narrow particle size distribution show high saturation magnetization and superpara-magnetism. The thermosensitive properties of the composite microspheres can be adjusted indirectly via controlling the addition amount of monomer (NIPAm) in the second step during controlled radical polymerization. Phenolphthalein was chosen as a model drug to investigate drug release behavior of the thermoresponsive magnetic composite microspheres with different shell thickness. Controlled drug release testing reveals that the release behavior depends on the thickness of polymer on the surface of the microspheres. (C) 2013 Elsevier Inc. All rights reserved.
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