Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 389, Issue -, Pages 292-297Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2012.08.065
Keywords
Batch-to-batch chemical inconsistency; Core-shell nanoparticles; Cytotoxicity; Prodrug; Targeted drug delivery
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada
- Nitrox Medical Devices
Ask authors/readers for more resources
Numerous samples of magnetite@silica and magnetite@silica@silane core-shell nanoparticles, previously used as prodrugs, were prepared by an experienced chemist, using the same identical equipment and the same lots of reagents. Their surface analyses showed batch-to-batch chemical variations: no two batches were found to have the same surface chemistries, showing unexpected Si-O bond scission and amine oxidation. Because the preparations used reactions recognized to be mild, and bond scission and oxidation were never previously reported for similar reactions on larger surfaces, the Fe3O4 nanoparticles that form the nanoparticle core appear to have acted as catalysts for these side reactions. The intended use of these nanoparticles, as drug carriers, is discussed in terms of cytotoxicological and biomedical consequences. (C) 2012 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available