Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 390, Issue -, Pages 47-53Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2012.09.035
Keywords
Atom transfer radical polymerization; Cholesterol; Dihexadecylglycerol; Self-assembly; Small-angle X-ray scattering; Zwitterionic polymer
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [20106007]
- Japan Society for Promotion of Sciences (JSPS) [22350101]
- Grants-in-Aid for Scientific Research [20106010, 20106007, 22350101] Funding Source: KAKEN
Ask authors/readers for more resources
As a model of lipopeptide, a zwitterionic polymer-lipid conjugate was prepared from carboxymethylbetaine monomer (CMB) using a lipophilic initiator having a cholesteryl or dihexadecylglyceryl end group for atom transfer radical polymerization (ATRP). The polymer-lipid conjugates (Lipid-PCMB) obtained could be dispersed in water, and self-association of the compounds could be characterized by both light scattering (dynamic light scattering, DLS; electrophoretic light scattering, ELS) and small-angle X-ray scattering (SAXS). DLS and ELS measurements showed no secondary aggregation of the self-associated Lipid-PCMB molecules in salt solutions, though their surfaces were almost charge-balanced. The hydrophilic PCMB layer of Lipid-PCMB aggregates gave rise to dispersions under ionic conditions. Furthermore, structural analyses by DLS, ELS and SAXS measurements suggested that Lipid-PCMB aggregates consisted of a hydrophobic lipid core and a hydrophilic PCMB layer, that is, a core-shell structure. To the best our knowledge, this is the first study in which SAXS analyses were performed for zwitterionic polymer-lipid conjugates. (C) 2012 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available