Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 372, Issue -, Pages 239-244Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2012.01.005
Keywords
Dual-modality imaging; Gold nanoclusters; Fluorescent; X-ray imaging; Contrast agents
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Funding
- National Natural Science Foundation of China [51003078, 81171393]
- Tongji University [2009KJ072]
- National Engineering Laboratory for Modern Silk, Soochow University
- Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, Soochow University [KJS1132]
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Multimodal imaging technique is an alternative approach to improve sensitivity of early cancer diagnosis. In this study, highly fluorescent and strong X-ray absorption coefficient gold nanoclusters (Au NCs) are synthesized as dual-modality imaging contrast agents (CAs) for fluorescent and X-ray dual-modality imaging. The experimental results show that the as-prepared Au NCs are well constructed with ultrasmall sizes, reliable fluorescent emission, high computed tomography (CT) value and fine biocompatibility. In vivo imaging results indicate that the obtained Au NCs are capable of fluorescent and X-ray enhanced imaging. (C) 2012 Elsevier Inc. All rights reserved.
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