Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 362, Issue 1, Pages 100-106Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2011.06.039
Keywords
Quantum dots; Antibiotics; Cooperative antimicrobial effects; Synchronous monitoring
Categories
Funding
- National Natural Science Foundation of China [51072134]
- State Major Research Plan (973) of China [2011CB932404]
- Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials [2012MCIMKF03]
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In this study, the cooperative antibacterial efficiency of CdTe quantum dots (QDs) and rocephin against Escherichia coli (E. coli) was investigated. Colony-forming capability assay and diameter of inhibition zone (DIZ) measurement showed the antibiotic action of CdTe QDs-rocephin complex was better than the superposition of pure CdTe QDs and rocephin. The fractional inhibitory concentration index (FICI) indicated that CdTe QDs-rocephin complex could achieve great cooperative antimicrobial effects. The infrared ray (IR) spectrum, photoluminescence (PL) spectrophotometry, and detection of reactive oxygen species (ROS) indicated that CdTe QDs and rocephin formed a stable antimicrobial group through electrostatic attraction and hydrogen bonds and then killed the E. coli together. Meanwhile, the fluorescence intensity of CdTe QDs and the optical density (OD) value of E. coli showed a good linear relationship. Thus, dynamic monitoring to total bacterial concentration in the antibacterial process was realized by the CdTe QDs. (C) 2011 Elsevier Inc. All rights reserved.
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