Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 363, Issue 2, Pages 465-475Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2011.07.067
Keywords
Zeolitic support; Clinoptilolite; Cationic surfactant; Drug adsolubilization; Drug release
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Funding
- Academy of Sciences [00-360 RG/CHE/LA, 07-016 RG/CHE/LA]
- Pole Universitaire Europeen de Montpellier
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The influence of different physical factors on the adsorption of the cationic surfactant benzalkonium chloride (BC) and the model drug sulfamethoxazole by a purified natural clinoptilolite (NZ) has been studied in order to employ zeolite-surfactant-drug composites as drug deliverer. It has been demonstrated that the adsorption of BC and sulfamethoxazole onto NZ depends of the time, the temperature, the ionic strength and the pH of the aqueous medium. The optimal conditions for the preparation of the zeolite-surfactant and zeolite-surfactant-drug composite materials are established. The results of the composite characterization support the presence of BC and sulfamethoxazole, as well as the structural stability of NZ during the treatments performed. The release experiments in acid medium demonstrate that the adsorption of sulfamethoxazole is reversible. It is also confirmed that the drug release profile corresponds to a diffusion or zero-order mechanism as a function of the compression pressure. (C) 2011 Elsevier Inc. All rights reserved.
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