Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 356, Issue 1, Pages 100-106Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2011.01.003
Keywords
Nano-gel; Graft copolymer; pH sensitive; Swelling; Polyaspartamide; Drug release
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Funding
- Korea government (MEST) [2010-0027955]
- National Research Foundation of Korea [2010-0029407] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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pH sensitive nano-gels based on polyaspartamide graft copolymers are prepared by UV crosslinking the self-assembled nano-aggregates in the presence of a series of hydrophobic and hydrophilic grafting segments. While the physical nano-aggregates dissociate via ionization of the pH sensitive moiety, the nano-gels synthesized in this study swell instead. The chemical structure and morphology of the resulting nano-gels were analyzed using FTIR, H-1 FTNMR, and TEM. The pH dependence of the particle size, 120-250 nm, was investigated using a light scattering analyzer. The swelling behavior of the nano-cores under acidic conditions triggered abrupt release of the drug; this pH dependence occurs reversibly and quickly. The nano-gels prepared may have endosomal rupturing characteristics, as their buffering capacity is as strong as that of uncrosslinked nano-aggregates. The nano-gels synthesized as such possess potential application as sustained releasing drug carriers for intracellular delivery. (C) 2011 Elsevier Inc. All rights reserved.
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