Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 359, Issue 2, Pages 399-406Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2011.04.032
Keywords
Lysozyme; Supramolecular hydrogel; In situ encapsulation; Sustained release
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Funding
- National Natural Science Foundation of China [21074152, 20874116]
- Natural Science Foundation of Guangdong Province in China [8151027501000004, 9151027501000105]
- Education Ministry in China [20090171110023]
- China Postdoctor Foundation [20100480802]
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To develop new matrices for the entrapment and sustained release of bioactive lysozyme, a series of supramolecular hydrogels based on alpha-cyclodextrin (alpha-CD) and water-soluble poly(epsilon-caprolactone)-poly(ethylene glycol) block copolymer (PCL-b-PEG) were prepared in the presence of chicken egg lysozyme. Different from commonly used polymeric microspheres and chemically crosslinked hydrogels for lysozyme encapsulation, such hydrogel matrices could be formed under mild conditions without high temperature and the use of chemical emulsifiers or crosslinkers. Their gelation rate, mechanical strength and shear viscosity as well as the release behavior for the encapsulated lysozyme could be tuned easily by the change of alpha-CD or PCL-b-PEG amount. For the encapsulated lysozyme, its conformation and biological activity could be well maintained when compared to native lysozyme. For the resultant supramolecular hydrogels, they were also confirmed to have a good biocompatibility by MET assay using mice skin fibroblast (L929). (C) 2011 Elsevier Inc. All rights reserved.
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