Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 358, Issue 2, Pages 392-398Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2011.03.051
Keywords
Hollow; Microsphere; Silica; Amino-functional; Ultrasound imaging; Sol-gel
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Funding
- Shanghai Natural Science Foundation [10ZR1422200]
- Shanghai Scientific Grant for Selection and Cultivation of Outstanding Young University Teachers [ssd10009]
- National Natural Science Foundation of China [50802059, 20971086]
- Shanghai Science, the Technology Development Fund [09QA1404300]
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By using the positive charged polystyrene (PS) microsphere as template, mono-disperse amino-(-NH2) functionalized hollow silica microspheres (HSMS-NH2) with similar to 1310 nm in diameter and uniform shells were successfully prepared with a modified sol-gel process. The amino functionalized silica were coated on the PS microspheres via ammonia catalysis, co-hydrolysis and condensation of TEOS and APTES, and then the PS templates were selectively dissolved in THF solution to form the functional hollow microspheres. The controllable thickness (35-85 nm) and amino density (2.46 x 10(-5)-6.18 x 10(-5) mol/g) of the shells could be facilely tuned by changing the amount of TEOS and APTES. In vitro ultrasound images of as-prepared HSMS-NH2 with different concentrations in the physiological saline solution were further investigated. The obvious signal enhancement indicates that as-prepared HSMS-NH2 has a great potential application for ultrasound imaging. (C) 2011 Elsevier Inc. All rights reserved.
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