Journal
JOURNAL OF COLLOID AND INTERFACE SCIENCE
Volume 343, Issue 1, Pages 125-133Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2009.10.002
Keywords
Electrospray; Controlled drug delivery; Morphology; Entanglements; Coulomb fission; Multiplexing
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Funding
- NSF [DMR-0907368]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [0907368] Funding Source: National Science Foundation
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We developed a well-controlled method to generate PLGA microparticles of different morphologies using the electrospray drying route. By Judiciously selecting polymer molecular weight, concentration, and solution flow rate, we call control the order in which polymer entanglements and Coulomb fission occur in the droplets and their relative importance, and subsequently govern the morphology of the resulting polymer particles. We show that spherical, monodisperse particles are generated when sufficiently strong polymer entanglements set in the evaporating droplets before they Undergo any Coulomb fission. On the other hand, tailed and elongated particles are obtained if the Coulomb fission occurs first and if the droplets/particles are sufficiently evaporated to freeze in their irregular shape. Strictly spherical particles are unachievable for polymer solutions below a critical concentration, because the closer of Coulomb, fission always sets in prior to the development of a sufficiently entangled polymer network. An extension of a simple model, originally used to determine the onset of electrospinning of polymer solutions, adequately predicts when non-spherical particles are produced. We conclude by demonstrating the scale-up of this approach to the synthesis of polymer particles using a compact, microfabricated, multiplexed electrospray system, which would make it suitable for practical applications. (C) 2009 Elsevier Inc. All rights reserved.
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