Patient with severe periodontitis and subgingival Epstein-Barr virus treated with antiviral therapy

It has been suggested that the presence of Epstein-Barr virus (EBV) can increase the severity of marginal periodontitis. We administered antiviral treatment (Valtrex (R) for a period of 10 days) to a patient with recurrent periodontal disease and a high EBV load subgingivally. The antiviral treatment decreased the presence of EBV to the detection limit and the periodontal condition improved dramatically. One year after treatment, the periodontal condition was still stable and the virus barely detectable. The case suggests that virus screening and subsequent antiviral therapy may be useful as an adjunct to conventional periodontal therapy. (c) 2008 Elsevier B.V. All rights reserved.