Related references
Note: Only part of the references are listed.Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science
Malcolm Rowland et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 51, 2011 (2011)
Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review
P. Zhao et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance
Trevor N. Johnson et al.
CLINICAL PHARMACOKINETICS (2010)
Pharmacokinetic modeling of the hepatobiliary transport mediated by cooperation of uptake and efflux transporters
Hiroyuki Kusuhara et al.
DRUG METABOLISM REVIEWS (2010)
Physiologically based mechanistic modelling to predict complex drug-drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut-The effect of diltiazem on the time-course of exposure to triazolam
Karen Rowland Yeo et al.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2010)
Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans
Takao Watanabe et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2010)
Assessment of the Impact of Renal Impairment on Systemic Exposure of New Molecular Entities: Evaluation of Recent New Drug Applications
Y. Zhang et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2009)
When to Conduct a Renal Impairment Study During Drug Development: US Food and Drug Administration Perspective
S-M Huang et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2009)
Drug Development Perspective on Pharmacokinetic Studies of New Drugs in Patients With Renal Impairment
R. L. Lalonde et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2009)
A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of 'Bottom-Up' vs 'Top-Down' Recognition of Covariates
Masoud Jamei et al.
DRUG METABOLISM AND PHARMACOKINETICS (2009)
The Simcyp® Population-based ADME Simulator
Masoud Jamei et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2009)
Physiology-Based Simulations of a Pathological Condition Prediction of Pharmacokinetics in Patients with Liver Cirrhosis
Andrea N. Edginton et al.
CLINICAL PHARMACOKINETICS (2008)
Effects of gemfibrozil and atorvastatin on the pharmacokinetics of repaglinide in relation to SLCO1B1 polymorphism
A. Kalliokoski et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)
Emerging evidence of the impact of kidney disease on drug metabolism and transport
T. D. Nolin et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)
Altered nonrenal drug clearance in ESRD
Thomas D. Nolin
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION (2008)
The effect of chronic renal failure on drug metabolism and transport
Albert W. Dreisbach et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)
Prediction of intestinal first-pass drug metabolism
Jiansong Yang et al.
CURRENT DRUG METABOLISM (2007)
Simulation and prediction of in vivo drug metabolism in human populations from in vitro data
Amin Rostami-Hodjegan et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs
Stefan Willmann et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2007)
Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions
Trudy Rodgers et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children
Trevor N. Johnson et al.
CLINICAL PHARMACOKINETICS (2006)
Development and evaluation of a generic physiologically based pharmacokinetic model for children
Andrea N. Edginton et al.
CLINICAL PHARMACOKINETICS (2006)
Cyclosporine markedly raises the plasma concentrations of repaglinide
LI Kajosaari et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2005)
Pharmacokinetics of telithromycin: application to dosing in the treatment of community-acquired respiratory tract infections
CA Ciervo et al.
CURRENT MEDICAL RESEARCH AND OPINION (2005)
Tissue distribution of basic drugs:: Accounting for enantiomeric, compound and regional differences amongst β-blocking drugs in rat
T Rodgers et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
Physiologically based pharmacokinetic modeling 1: Predicting the tissue distribution of moderate-to-strong bases
T Rodgers et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
Clinical pharmacokinetics of telithromycin, the first ketolide antibacterial
J Shi et al.
CLINICAL PHARMACOKINETICS (2005)
Pharmacokinetics and safety of the ketolide telithromycin in patients with renal impairment
J Shi et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2004)
Cytochrome P450 3A expression and activity in the human small intestine
JS Yang et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2004)
Hepatic drug metabolism and transport in patients with kidney disease
TD Nolin et al.
AMERICAN JOURNAL OF KIDNEY DISEASES (2003)
Pharmacokinetics and absolute oral bioavailability of an 800-mg oral dose of telithromycin in healthy young and elderly volunteers
C Perret et al.
CHEMOTHERAPY (2002)
Comparative human pharmacokinetics and metabolism of single-dose oral and intravenous sildenafil citrate
GJ Muirhead et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2002)
The effects of age and renal and hepatic impairment on the pharmacokinetics of sildenafil citrate
GJ Muirhead et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2002)
The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil citrate in healthy volunteers
GJ Muirhead et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2002)
Pharmacokinetics of sildenafil citrate after single oral doses in healthy male subjects: absolute bioavailability, food effects and dose proportionality
DJ Nichols et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2002)
Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil
R Hyland et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2001)
Pharmacokinetics of repaglinide in subjects with renal impairment
TC Marbury et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2000)
Share Paper
