Journal
JOURNAL OF CLINICAL PHARMACOLOGY
Volume 48, Issue 12, Pages 1400-1410Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0091270008322906
Keywords
Heart failure; cyclic GMP; soluble guanylate cyclase; drug therapy; phase I clinical trial
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Funding
- Bayer HealthCare AG
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Preclinical data indicate that the nitric oxide-independent soluble guanylate cyclase activator cinaciguat (BAY 58-2667), which is a new drug in development for patients with heart failure, induces vasodilation preferentially in diseased vessels. This study aimed to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinaciguat. Seventy-six healthy volunteers were included in this randomized, placebo-controlled study. Cinaciguat (50-250 mu g/h) was administered intravenously for up to 4 hours in a maximum of 6 individuals per dose group. No serious adverse events were reported. Four-hour infusions (50-250 mu g/h) decreased diastolic blood pressure and increased heart rate (all P values < .05) versus placebo, without significantly reducing systolic blood pressure P between 0.07 and 0.56). At higher doses (150-250 mu g/h), 4-hour infusions decreased mean arterial pressure and increased plasma cyclic guanosine monophosphate levels (all P values < .05). Pharmacokinetics showed dose-proportionality with low interindividual variability. Plasma concentrations declined below 1.0 mu g/L within 30 minutes of cessation of infusion. Cinaciguat had potent cardiovascular effects reducing preload and afterload, warranting further investigation in patients with heart failure.
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