Journal
JOURNAL OF CLINICAL PATHOLOGY
Volume 63, Issue 4, Pages 322-329Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/jcp.2009.071035
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Funding
- Fundacao para a Ciencia e a Tecnologia e -FCT [PTDC/SAU-MII/64153/2006, PIC/IC/82716/2007]
- Fundação para a Ciência e a Tecnologia [PIC/IC/82716/2007, PTDC/SAU-MII/64153/2006] Funding Source: FCT
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Glycoconjugates constitute a major class of biomolecules which include glycoproteins, glycosphingolipids and proteoglycans. Glycans are involved in several physiological and pathological conditions, such as host-epathogen interactions, cell differentiation, migration, tumour invasion and metastisation, cell trafficking and signalling. Cancer is associated with glycosylation alterations in glycoproteins and glycolipids. This review describes various aspects of protein glycosylation with the focus on alterations associated with human cancer. The application of these glycosylation modifications as biomarkers for cancer detection in tumour tissues and serological assays is summarised.
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