Journal
JOURNAL OF CLINICAL PATHOLOGY
Volume 62, Issue 5, Pages 422-428Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/jcp.2008.060681
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Funding
- University of Nottingham
- Breakthrough Breast Cancer Research Centre
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MicroRNAs (miRNAs) are a highly abundant class of endogenous small non-coding RNAs (18-25 nucleotides in length) that regulate gene expression by targeting protein-coding mRNAs post-transcriptionally. miRNAs have been implicated in cancer development and progression. As miRNAs and their regulatory functions are further revealed, the more the importance of miRNA-directed gene regulation is emphasised. In the human genome, 695 mature miRNAs have been identified, although computational calculation predicts that this may increase to >1000. Deregulation of miRNA expression profiles is thought to be implicated in the pathogenesis of many human cancers including breast tumours. Breast cancer subtypes are observed to have deranged miRNA expression signatures, which makes miRNAs important targets for developing a novel molecular classification of breast cancer and opening avenues for more individualised treatment strategies for patients with breast cancer.
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