Journal
NEW PHYTOLOGIST
Volume 210, Issue 1, Pages 58-64Publisher
WILEY
DOI: 10.1111/nph.13564
Keywords
biotechnology; geminivirus; gene editing; genome editing; genome engineering; replicon; vector
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Funding
- Shanghai Center for Plant Stress Biology of the Chinese Academy of Sciences
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Viruses are intracellular pathogens that have evolved efficient strategies for replication and expression of their proteins in the host cells. Geminiviruses - plant viruses with small circular single-stranded DNA genomes - effectively manipulate plant cell processes for viral functions, entailing great potential for biotechnological applications. This potentiality has been realized in the form of protein expression and gene-silencing vectors, and, more recently, vectors for genome editing - a technology that these viruses seem particularly well-suited to facilitate. This insight offers an overview of the biological properties of geminiviruses, with emphasis on those leveraging development of geminivirus-based replicons. It illustrates the basis for engineering geminivirus-based replicons and their applications. Furthermore, it discusses the reported use and future perspectives of geminivirus-based replicons for genome editing.
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