Journal
JOURNAL OF CLINICAL ONCOLOGY
Volume 30, Issue 30, Pages 3675-3686Publisher
AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/JCO.2012.43.0116
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Funding
- National Cancer Institute, Bethesda, MD [R01 CA87845, R01 CA101318, R01 CA129769, U54 CA132378]
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Cognitive changes associated with cancer and cancer treatments have become an increasing concern. Using breast cancer as the prototype, we reviewed the research from neuropsychological, imaging, genetic, and animal studies that have examined pre- and post-treatment cognitive change. An impressive body of research supports the contention that a subgroup of patients is vulnerable to post-treatment cognitive problems. We also propose that models of aging may be a useful conceptual framework for guiding research in this area and suggest that a useful perspective may be viewing cognitive change in patients with cancer within the context of factors that influence the trajectory of normal aging.
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