Nanocatalytic one-pot, four-component synthesis of some new triheterocyclic compounds consisting of pyrazole, pyran, and pyrimidinone rings

A new series of triheterocyclic compounds containing pyrazole, pyran, and pyrimidinone rings was synthesized via a one-pot condensation of ethylacetoacetate, hydrazine hydrate, barbituric acid, and aromatic aldehydes in the presence of catalytic amounts of titanium dioxide nanowires. Various functional groups were well tolerated under the optimized reaction conditions.