Journal
NEW JOURNAL OF CHEMISTRY
Volume 39, Issue 2, Pages 800-804Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4nj01758g
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Funding
- NSF of China [21271072]
- Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning
- Shanghai Pujiang Program [13PJ1401900]
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A novel Pt-IV-azide@carbon dots (CDs) nanoplatform for photo-controlled targeted platinum drug delivery was developed. The Pt-IV-N-3-FA@CDs nanoplatform selectively targeted folate-receptor overexpressed cancer cells while being simultaneously traced based on its inherent fluorescence; and it showed no dark cytotoxicity even in the presence of reducing glutathione, whereas it was readily photo-activated by either UV or visible light, producing cytotoxicity at a level comparable with that of cisplatin.
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