Journal
JOURNAL OF CLINICAL NEUROSCIENCE
Volume 19, Issue 3, Pages 370-374Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2011.07.025
Keywords
Pituitary gland; Progression-free survival; Radiotherapy; Radiological progression; Stereotactic radiotherapy
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Non-functioning pituitary adenomas are primarily a surgically managed pathology, but recurrence or regrowth is not uncommon. Previous large series have retrospectively validated the use of the Gamma Knife (GK) as an adjuvant treatment. To our knowledge, we present the largest case series to date with the Linear Accelerator (Linac) for the management of this pathology. In this study we review the clinical course of 118 patients, 51 of whom had stereotactic radiosurgery (SRS) and 67 who had fractionated stereotactic radiotherapy (FSRT); the discriminatory feature being proximity to the optic chiasm. For comparison purposes a population of 53 patients who had conventional radiotherapy (CRT) is included. The local control rates at 5 years for SRS, FRST and CRT were 100%, 93% and 87% respectively. Treatment-related morbidity was low. These data confirm that Linac SRS and FSRT are safe and effective for the treatment of non-functioning pituitary adenomas. (C) 2011 Elsevier Ltd. All rights reserved.
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