Journal
JOURNAL OF CLINICAL NEUROSCIENCE
Volume 17, Issue 4, Pages 501-505Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2009.07.110
Keywords
Intraneural blood flow; Compound nerve action potential; Graded compressive force; Blood-nerve barrier; Rabbit sciatic nerve
Categories
Ask authors/readers for more resources
Entrapment neuropathy is a frequent clinical problem that can be caused by, among other factors. mechanical compression: however, exactly how a compressive force affects the peripheral nerves remains poorly understood. In this study, using a rabbit model of sciatic nerve injury (n = 12), we evaluated the time-course of changes in intraneural blood flow, compound nerve action potentials, and functioning of the blood-nerve barrier during graded mechanical compression. Nerve injury was applied using a compressor equipped with a custom-made pressure transducer. Cessation of intraneural blood flow was noted at a mean compressive force of 0.457 +/- 0.022 N ( +/-SEM), and the compound action potential became zero at 0.486 +/- 0.031 N. Marked extravasation of Evans blue albumin was noted after 20 min of intraneural ischemia. The functional changes induced by compression are likely clue to intraneural edema, which could subsequently result in impairment of nerve function. These changes may be critical factors in the development of symptoms associated with nerve compression. (C) 2009 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available