Journal
JOURNAL OF CLINICAL NEUROSCIENCE
Volume 17, Issue 5, Pages 654-655Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2009.09.026
Keywords
Multiple sclerosis; Parkinsonism; MRI; Intravenous methylprednisolone; Interferon beta 1a
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Parkinsonism due to multiple sclerosis (MS) is rare. In previously reported patients with MS-induced parkinsonism, MS manifested first, followed a typical clinical course, and parkinsonism developed later in the course of the illness. We report a 52-year-old male presenting with parkinsonism as the initial manifestation of MS, in whom a subsequent MS relapse consisted of marked deterioration in parkinsonism, a clinical pattern not previously described in MS. A brain MRI demonstrated involvement of the substantia nigra and basal ganglia. This patient illustrates that the clinical presentation and progression of MS may rarely be characterised by predominating parkinsonian features which are reversible by treatment with intravenous methylprednisolone and interferon beta 1a. (C) 2009 Elsevier Ltd. All rights reserved.
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