Journal
JOURNAL OF CLINICAL NEUROSCIENCE
Volume 16, Issue 9, Pages 1131-1135Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2009.03.005
Keywords
Frontotemporal dementia; Motor neurone disease; Frontal dysfunction
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Funding
- Government of Chile
- Australian Research Council Federation Fellowship
- Medical Research Council [G9724461] Funding Source: researchfish
- MRC [G9724461] Funding Source: UKRI
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Advances in genetics and pathology have supported the idea of a continuum between frontotemporal dementia (FTD) and motor neurone disease (MISID), which is strengthened by the discovery of the trans-activating responsive (Tar) sequence DNA binding protein (TDP-43) as a key component in the underlying pathology of FTD, FTD-MND and sporadic and familial MND patients. MIND is a multisystem disorder associated with cognitive and behavioural changes which in some instances reaches the criteria for FTD, while a proportion of patients with FTD develop frank MIND. We review the overlap between FTD and MND, emphasizing areas of controversy and uncertainty. (C) 2009 Published by Elsevier Ltd.
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