Journal
JOURNAL OF CLINICAL NEUROSCIENCE
Volume 15, Issue 2, Pages 130-137Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jocn.2007.02.089
Keywords
multiple sclerosis; magnetic resonance imaging; biological markers; atrophy; disease progression; patient monitoring
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Linear measures of cerebral ventricular enlargement may act as surrogate measures of cerebral atrophy in multiple sclerosis (MS). Linear atrophy markers were measured from routine MRI scans during a population survey of 171 Tasmanian MS patients and 91 healthy controls. Thirty-five Victorian MS clinic patients were recruited as a validation cohort with 14 of these re-assessed 4 years later. In the population survey, we measured three linear brain atrophy markers: inter-caudate distance (ICD), third ventricle width (TVW) and frontal horn width (FHW). TVW (OR 2.0, p = 0.001) and ICD (OR 16.1, p < 0.001) differentiated between MS cases and controls. In the validation study, we correlated the intercaudate ratio (ICR = ICD/brain width) and third ventricular ratio (TVR = TVW/brain width) with brain parenchymal volume. Cross-sectionally, ICR (R = -0.453, p < 0.01) and TVR (R = -0.653, p < 0.01) were correlated with brain parenchymal volume. Longitudinally, brain parenchymal volume loss was inversely correlated with increased ICD (R = -0.77, p < 0.01) and TVW (R = -0.71, p < 0.01). This study shows that ICD measurements obtained from clinical MRI scans are valid brain atrophy measures for use in monitoring MS progression. (c) 2007 Elsevier Ltd. All rights reserved.
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