Journal
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
Volume 28, Issue 2, Pages 146-153Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNP.0b013e31821213d4
Keywords
Circadian patterns; Epilepsy; Seizures; Epilepsy monitoring; Chronobiology
Categories
Ask authors/readers for more resources
The combination of chronobiology and epilepsy offers novel diagnostic and therapeutic management options. Knowledge of the interactions between circadian periodicity, entrainment, sleep patterns, and epilepsy may provide additional diagnostic options beyond sleep deprivation and extended release medication formulations. It may also provide novel insights into the physiologic, biochemical, and genetic regulation processes of epilepsy and the circadian clock, rendering new treatment options. Temporal fluctuations of seizure susceptibility based on sleep homeostasis and circadian phase in selected epilepsies may provide predictability based on mathematical models. Chrono-epileptology offers opportunities for individualized patient-oriented treatment paradigms based on chrono-pharmacology, differential medication dosing, chrono-drug delivery systems, and utilization of zeitgebers such as chronobiotics or light-therapy and desynchronization strategies among others.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available